Toxigenic molds in water-damaged buildings: dechlorogriseofulvins from Memnoniella echinata.
Jarvis-BB; Zhou-Y; Jiang-J; Wang-S; Sorenson-WG; Hintikka-L; Nikulin-M; Parikka-P; Etzel-RA; Dearborn-DG
J Nat Prod 1996 Jun; 59(6):553-554
A cluster of cases of pulmonary hemosiderosis was reported in infants in Cleveland, Ohio, which resulted in an investigation of dampness in the homes of these infants as a common factor. In each home, varying levels of contamination by Stachybotrys-atra was found. Two isolates of Memnoniella-echinata were also noted whose cultures proved cytotoxic against fetal feline lung cells. One isolate was grown on rice for 30 days, extracted and chromatographed providing a number of fractions several of which were highly cytotoxic. Two of the fractions yielded trichodermol (2198938) and trichodermin (4682502). A low cytotoxic fraction yielded dechlorogriseofulvin and epidechlorogriseofulvin. The production of such a wide variety of cytotoxins and immunosuppressants contributes significantly to the toxicity of these organisms.
NIOSH-Author; Cytotoxins; Neonates; Mycotoxins; Microorganisms; Environmental-exposure; Respiratory-system-disorders; Epidemiology; Fungi; Risk-factors; Lung-disease
Journal of Natural Products