Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Toxigenic molds in water-damaged buildings: dechlorogriseofulvins from Memnoniella echinata.

Authors
Jarvis-BB; Zhou-Y; Jiang-J; Wang-S; Sorenson-WG; Hintikka-L; Nikulin-M; Parikka-P; Etzel-RA; Dearborn-DG
Source
J Nat Prod 1996 Jun; 59(6):553-554
NIOSHTIC No.
00232642
Abstract
A cluster of cases of pulmonary hemosiderosis was reported in infants in Cleveland, Ohio, which resulted in an investigation of dampness in the homes of these infants as a common factor. In each home, varying levels of contamination by Stachybotrys-atra was found. Two isolates of Memnoniella-echinata were also noted whose cultures proved cytotoxic against fetal feline lung cells. One isolate was grown on rice for 30 days, extracted and chromatographed providing a number of fractions several of which were highly cytotoxic. Two of the fractions yielded trichodermol (2198938) and trichodermin (4682502). A low cytotoxic fraction yielded dechlorogriseofulvin and epidechlorogriseofulvin. The production of such a wide variety of cytotoxins and immunosuppressants contributes significantly to the toxicity of these organisms.
Keywords
NIOSH-Author; Cytotoxins; Neonates; Mycotoxins; Microorganisms; Environmental-exposure; Respiratory-system-disorders; Epidemiology; Fungi; Risk-factors; Lung-disease
CODEN
JNPRDF
CAS No.
2198-93-8; 4682-50-2
Publication Date
19960622
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0163-3864
NIOSH Division
DRDS
Priority Area
Respiratory-system-disorders
Source Name
Journal of Natural Products
State
WV; MD; GA; OH
TOP