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Taurine content of isolated rat alveolar yype I cells.

Authors
Banks-MA; Porter-DW; Pailes-WH; Schwegler-Berry-D; Martin-WG; Castranova-V
Source
Comp Biochem Physiol B Comp Biochem 1991 Oct-Dec; 100(4):795-799
NIOSHTIC No.
00232620
Abstract
The taurine content of rat alveolar type-I cells was compared to that found in alveolar macrophages and type-II cells, and a correlation was made between intracellular taurine levels and susceptibility to oxidant induced injury. The type-I cells were isolated by enzymatic digestion and purified by centrifugal elutriation and specific surface absorption. Sprague-Dawley-rats were used for the study. Taurine levels in alveolar macrophages ranged from 3.86 to 4.68 millimolar (mM), in alveolar type-II epithelial cells from 13.45 to 15.35mM, and in alveolar type-I epithelial cells from 0.07 to 0.21mM, approaching that found in rat plasma, 0.1mM. The authors suggest that type-I cells lack the specialized transport pathway for the active accumulation of taurine. The correlation noted between the rate of oxygen metabolism and intracellular taurine content may involve calcium homeostasis. Cells which are low in taurine would be expected to have low rates of oxygen consumption. The authors conclude that taurine may possess antioxidant properties which are protective to type-II cells and macrophages.
Keywords
NIOSH-Author; Lung-cells; Cytotoxic-effects; Laboratory-animals; Cell-damage; Oxidation; Antioxidants; In-vitro-studies
CODEN
CBPBB8
Publication Date
19911001
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0305-0491
NIOSH Division
DRDS
Source Name
Comparative Biochemistry and Physiology, Part B: Comparative Biochemistry
State
WV
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