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Restrictive lung function and asbestos-induced pleural fibrosis. A quantitative approach.

Authors
Schwartz-DA; Galvin-JR; Yagla-SJ; Speakman-SB; Merchant-JA; Hunninghake-GW
Source
J Clin Invest 1993 Jun; 91(6):2685-2692
NIOSHTIC No.
00232510
Abstract
The use of a computer algorithm for the three dimensional reconstruction of high resolution computerized tomography chest scans in asbestos (1332214) exposed subjects was described. The three dimensional reconstruction was used to determine the volume of asbestos induced pleural fibrosis in the subjects. Of the 60 subjects studied, fibrosis was identified in the scans from 29. The volumes of the pleural lesions within this group ranged from 0.01% to 7.11% of the total chest cavity. Comparison of the computer derived estimate of pleural fibrosis with total lung capacity indicated an inverse relationship between these measures. This relationship remained in a multivariate analysis controlling for factors such as age, height, cigarette smoking, and the presence of interstitial fibrosis and independently accounted for 9.5% of the variance of this measure of lung volume. Each milliliter of pleural fibrosis was found to be independently associated with a 5 milliliter decrement in total lung capacity. The authors conclude that these data support an independent association between pleural fibrosis and restrictive lung function.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Computer-models; Lung-function; Asbestosis; Lung-fibrosis
Contact
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
CODEN
JCINAO
CAS No.
1332-21-4
Publication Date
19930601
Document Type
Journal Article
Funding Amount
122514
Funding Type
Grant
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093
Issue of Publication
6
ISSN
0021-9738
Priority Area
Pulmonary System Disorders
Source Name
Journal of Clinical Investigation
State
ME; IA
Performing Organization
University of Iowa, Iowa City, Iowa
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