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Properties of lavage material from excised lungs ventilated at different temperatures.

Authors
Miles-PR; Bowman-L; Frazer-DG
Source
Respir Physiol 1995 Jul; 101(1):99-108
NIOSHTIC No.
00232505
Abstract
The effects of ventilation temperature on properties of pulmonary lavage material were studied in excised lungs. Lavage from freshly excised rat lungs and excised lungs which had been ventilated at 22, 37, and 42 degrees-C were examined for phospholipid and protein contents, composition of phospholipids, and some surface properties. No differences in the phospholipid composition or surface properties of lavage materials were seen between freshly excised lungs or lungs ventilated at 22 degrees, although slightly more lavageable phospholipids and protein was obtained in the ventilated lungs. Increasing the ventilation temperature of the excised lungs decreased lavage fluid phospholipid content and the relative amounts of total phosphatidylcholine and disaturated phosphatidylcholines and increased unsaturated phosphatidylcholines and total protein and nonsedimentable protein. Lavage material from lungs ventilated at 37 degrees had increased maximum surface tension and those ventilated at 42 degrees had increased maximum and minimum surface tension values. The authors conclude that ventilation temperature affects the composition and surface properties of alveolar lavage materials from excised lungs.
Keywords
NIOSH-Author; Temperature-effects; Surfactants; Surface-properties; Chemical-composition; Pulmonary-system; Laboratory-animals; Author Keywords: Mammals; rat; Surfactant; pulmonary; composition; Temperature; pulmonary surfactant
Contact
P.R. Miles, Division of Respiratory Disease Studies Appalachian Laboratory for Occupational Safety and Health Morgantown, Morgantown, WV 26505, USA
CODEN
RSPYAK
Publication Date
19950701
Document Type
Journal Article
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0034-5687
NIOSH Division
DRDS
Source Name
Respiration Physiology
State
WV
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