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Methodological considerations relevant to epidemiology studies of silica and lung cancer.

Authors
Checkoway-H
Source
Appl Occup Environ Hyg 1995 Dec; 10(12):1049-1055
NIOSHTIC No.
00232480
Abstract
Methodological factors affecting the interpretation of epidemiological studies examining the relationship between occupational exposure to silica (14808607) and lung cancer were reviewed. Data from three studies of Vermont granite workers, South African gold miners, and California diatomaceous earth mining and processing workers were used to illustrate methodological shortcomings in the quality of exposure assessment, control of confounders such as other workplace exposures and cigarette smoking, and the use of pulmonary fibrosis as a precursor to lung cancer. Sources of bias in epidemiologic research, particularly in studies of occupational exposures and lung cancer, were described and discussed. The author presented several recommendations to improve the quality of epidemiologic studies examining occupational silica exposure and lung cancer risk.
Keywords
Pulmonary-system-disorders; Epidemiology; Analytical-methods; Silica-dusts; Lung-cancer; Risk-factors; Cigarette-smoking; Statistical-analysis; Mining-industry; Occupational-exposure;
Contact
Environmental Health University of Washington SC-34 Seattle, WA 98195
CODEN
AOEHE9
CAS No.
14808-60-7
Publication Date
19951201
Document Type
Journal Article
Funding Amount
381670
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003126
Issue of Publication
12
ISSN
1047-322X
Source Name
Applied Occupational and Environmental Hygiene
State
CA; VT; WA
Performing Organization
University of Washington, Seattle, Washington
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