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Lung peptidases, including carboxypeptidase, modulate airway reactivity to intravenous bradykinin.

Authors
Chodimella-V; Skidgel-RA; Krowiak-EJ; Murlas-CG
Source
Am Rev Respir Dis 1991 Oct; 144(4):869-874
NIOSHTIC No.
00232472
Abstract
A study was undertaken to determine the effect of inhibition of endogenous carboxypeptidase, neutral endopeptidase, or angiotensin converting enzyme on airway reactivity to the peptide hormone bradykinin. Specific airway resistance was measured in male Hartley- guinea-pigs before and after receiving intravenous injections of the enzyme inhibitors 2-mercaptomethyl-3-guanidinoethylthiopropanoic- acid (MGTA), phosphoramidon, or captopril. Reactivity to increasing doses of intravenous bradykinin was measured in guinea-pigs following these exposures. Phosphoramidon and captopril, either alone or in combination, were observed to increase airway reactivity to bradykinin, but did not affect muscarinic activity. MGTA did not have any significant effect on airway reactivity, although it was associated with significantly increased reactivity in the presence of phosphoramidon and captopril. The authors conclude that airway reactivity to bradykinin is regulated by lung cell membrane carboxypeptidase, endopeptidase, and angiotensin converting enzyme, and that the influence of carboxypeptidase increases when the activities of neutral endopeptidase and angiotensin converting enzyme are reduced.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Pulmonary-function; Enzymes; Hormone-activity; Enzyme-inhibitors; Lung-function; Physiological-response; Physiological-function
Contact
Christopher Murlas, M.D., Department of Medicine (Pulmonary), Rush University, 1653 West Congress Parkway, Chicago, IL 60612
CODEN
ARDSBL
Publication Date
19911001
Document Type
Journal Article
Funding Amount
127961
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00060
Issue of Publication
4
ISSN
0003-0805
Priority Area
Pulmonary-system-disorders
Source Name
American Review of Respiratory Disease
State
OH; IL
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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