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Interlaboratory comparison of non-fibrous particle lung burden quantification techniques.

Authors
Abraham-JL; Stettler-LE; Burnett-B; Hunt-A; Platek-SF
Source
Ann Occup Hyg, Inhaled Particles VII 1994 Jan; 38(Suppl 1):541-550
NIOSHTIC No.
00232467
Abstract
An investigation was undertaken to determine the effectiveness of three different approaches to the use of scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods for the quantification of lung particle burden. Ten previously examined lung tissue samples were used in this study. Samples were analyzed using a manual in-situ method with 5 micrometer tissue sections (SUNY-in-situ), manual analysis of particles extracted via tissue digestion (SUNY-digestion), and automated techniques on ashed tissue (NIOSH). All three analytical approaches revealed the same profile of particle types, though the methods did not yield consistent results in absolute particle concentrations. Strong Spearman rank order correlations were seen between the SUNY-in-situ and SUNY- digestion methods, and between the SUNY-digestion and NIOSH methods. From this study the authors conclude that discrepancies in the results obtained using the different analytical approaches are possibly attributable to differences in sample preparation methods and variations in minimum size thresholds.
Keywords
NIOSH-Author; Analytical-methods; Microscopic-analysis; Lung-tissue; X-ray-analysis; Lung-burden; Particulates; Quantitative-analysis
CODEN
AOHYA3
Publication Date
19940101
Document Type
Journal Article; Conference/Symposia Proceedings; Book or book chapter
Editors
Dodgson-J; McCallum-RI
Fiscal Year
1994
NTIS Accession No.
NTIS Price
ISBN No.
0080408419
ISSN
0003-4878
NIOSH Division
DBBS
Source Name
Annals of Occupational Hygiene, Inhaled Particles VII
State
OH; WV
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