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Effects of ammonium metavanadate treatment upon macrophage glutathione redox cycle activity, superoxide production, and intracellular glutathione status.

Authors
Cohen-MD; Wei-CI
Source
J Leukoc Biol 1988 Aug; 44(2):122-129
NIOSHTIC No.
00232394
Abstract
B6C3F1-mice were administered ammonium-metavanadate (7803556) at 10mg/kg, or 2.5mg/kg as vanadium (7440622) intraperitoneally every 3 days for 6 weeks, and the effects on three enzymes involved in energy production for phagocytosis and for the removal of peroxides, as well as the production of superoxide anion were studied. An attempt was made to determine whether vanadate pretreatment could contribute to the observed depressed phagocyte responses and Listeria killing by inhibiting enzymes related to the respiratory burst in peritoneal macrophages (PEM). These enzymes included glucose-6-phosphate-dehydrogenase, glutathione-reductase and glutathione-peroxidase. The results clearly showed that intraperitoneal exposure of mice to vanadium for 6 weeks could affect the three cytoplasmic enzymes which are crucial for PEM function, as well as the level of substrate required for their proper activity. The authors suggest that their 6 week exposure period may serve as a model for analyzing the effects of vanadium on macrophage function after long term exposure.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Vanadium-compounds; Enzyme-activity; Oxidative-metabolism; Laboratory-animals; Toxic-effects
Contact
Food Science & Human Nutrition University of Florida Gainesville, FL 32611 Gainesville, FL 32611
CODEN
JLBIE7
CAS No.
7803-55-6; 7440-62-2
Publication Date
19880801
Document Type
Journal Article
Funding Amount
43500.00
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-02583
Issue of Publication
2
Priority Area
Grants-other
Source Name
Journal of Leukocyte Biology
State
FL
Performing Organization
University of Florida, Gainesville, Florida
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