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Pathogenesis of airway hyperreactivity.

Authors
Murlas-CG
Source
Chest 1988 Jun; 93(6):1278-1280
NIOSHTIC No.
00232161
Abstract
Current scientific opinions and data concerning airway hyperreactivity and the mechanisms causing this to occur were reviewed and discussed. The review focused on information which may offer insight into the mechanisms by which airway injury results in acute airway hyperreactivity. Investigators have studied acute experimental airway disorders in animals characterized, at least in part, by hyperreactivity. At the start of hyperreactivity there appears to be no increase in inflammatory cells, but this rapidly changes. Rather than being a cause of airway hyperreactivity, however, neutrophilic infiltration of the airways appears as a consequence of the acute, nonimmunologic airway injury producing the hyperreactivity. The hypothesis that neutrophilic infiltration causes the acute increase in airway reactivity during an asthma attack is flawed by the finding that such attacks are associated with airway eosinophilic and not neutrophilic infiltration and exudation. The author suggests that the early onset increase in reactivity after immunologic airway injury is related to the generation by normal lung cell constituents of mediators that increase reactivity status. The author suggests that the cellular events causing hyperreactivity do so by increasing airway neuromuscular responsiveness and not by producing tissue inflammatory cell infiltration or edema. Several possible mechanisms for the potentiation of one bronchoconstrictor's effect by another at airway neuromuscular junctions were presented.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Lung-function; Pulmonary-function; Bronchial-asthma
Contact
Internal Medicine Univ of Tennessee, Memphis 956 Court Avenue Memphis, TN 38163
CODEN
CHETBF
Publication Date
19880601
Document Type
Journal Article
Funding Amount
127961
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00060
Issue of Publication
6
ISSN
0012-3692
Priority Area
Pulmonary-system-disorders
Source Name
Chest
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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