Prednisone pretreatment leads to histaminic airway hyporeactivity soon after resolution of the immediate allergic response.
Steinberg-DR; Bernstein-DI; Bernstein-IL; Murlas-CG
Chest 1989 Feb; 95(2):314-319
A group of four subjects, in whom dual phase responses following inhalation of bluegrass allergen had been previously documented, were studied to examine the effect of prednisone pretreatment on the development of the early increase in histamine reactivity which occurs soon after resolution of the immediate response in allergic humans. A second study group included four subjects who had been shown to manifest only isolated immediate responses following bluegrass allergen inhalation. Subjects had baseline histamine airway challenges post allergen and subsequent to prednisone pretreatment. The increase in airway reactivity occurring soon after resolution of the immediate response induced by allergens is inhibited by prednisone. Soon after resolution of the immediate response in both atopic groups, the histaminic reactivity had actually decreased significantly in relation to values determined prior to allergen exposure. The authors suggest that such a change in reactivity in both isolated and dual phase responders may be a result of inflammatory cell accumulation in the airway tissue microvasculature. The authors note that the prednisone effect is not dependent on its potential influence on the influx of inflammatory cells into diseased airways.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Bronchial-asthma; Airway-resistance; Allergic-disorders; Allergic-reactions; Steroids; Humans
Internal Medicine Univ of Tennessee, Memphis 956 Court Avenue Memphis, TN 38163
University of Cincinnati, Cincinnati, Ohio