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Identification of a major human urinary metabolite of alachlor by LC- MS/MS.

Authors
Driskell-WJ; Hill-RH Jr.; Shealy-DB; Hull-RD; Hines-CJ
Source
Bull Environ Contam Toxicol 1996 Jun; 56(6):853-859
NIOSHTIC No.
00231592
Abstract
Urinary metabolites of the herbicide alachlor (15972608) were identified in occupationally exposed subjects by liquid chromatography coupled to mass spectrometry. Urine samples were collected from four workers; daughter and parent scanning modes were then utilized to identify alachlor metabolites. On the basis of mass spectrometry and chromatographic behavior, the major metabolite was identified as alachlor-mercapturate. A method was then developed to measured this metabolite in urine. In the four urinary samples, alachlor-mercapturate levels ranged from 25 to 62% of the concentration of the alachlor hydrolysis product, 2,6-diethylaniline (579668) (DEA). No other alachlor metabolites were positively identified. The authors conclude that identification of alachlor- mercapturate allows for the development of novel methods to assess alachlor exposure and enable more effective biomonitoring; a method based on measurement of this metabolite should prove to be simpler, safer, and more specific than the previously used DEA method.
Keywords
NIOSH-Author; Occupational-exposure; Herbicides; Biological-monitoring; Analytical-methods; Chromatographic-analysis; Urinalysis; Urine-chemistry; Mass-spectrometry
CODEN
BECTA6
CAS No.
15972-60-8; 579-66-8
Publication Date
19960601
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0007-4861
Source Name
Bulletin of Environmental Contamination and Toxicology
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