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Risk of nervous system cancer among workers exposed to lead.

Authors
Anttila-A; Heikkila-P; Nykyri-E; Kauppinen-T; Pukkala-E; Hernberg-S; Hemminki-K
Source
J Occup Environ Med 1996 Feb; 38(2):131-136
NIOSHTIC No.
00230799
Abstract
The risk of cancer of the nervous system due to occupational exposure to lead was investigated. The incidence of nervous system cancer in 18,329 men and 2,412 women, whose blood lead (7439921) concentrations were monitored during the period of 1973 to 1983, was determined using the Finnish Cancer Registry for the period 1973 through 1988. A nested case/referent study was conducted to assess the associations of nervous system cancer with indices of lifetime lead exposure; followup was through 1990. There were 26 cases and 200 matched referents. Living cases or next of kin complete a questionnaire concerning work history, smoking, and alcohol consumption. Workers with blood lead levels greater than or equal to 1.4 micromole/liter had a two fold increase in the odds ratio for nervous system cancer, compared to workers with blood lead levels at or below 0.7 micromole/liter. There was an age specific increase in the risk of nervous system cancer, which was explained by an increase in the risk of gliomas. Lifetime exposure to lead was found to be associated with the incidence of glioma. The authors conclude that occupational exposure to lead, alone or in combination with other agents may be associated with an increased risk of gliomas.
Keywords
NIOSH-Publication; NIOSH-Grant; Cancer; Occupational-exposure; Heavy-metals; Nervous-system-disorders; Epidemiology; Cancer-rates; Humans; Central-nervous-system
Contact
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
CODEN
JOEMFM
CAS No.
7439-92-1
Publication Date
19960201
Document Type
Journal Article
Funding Amount
102342
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00076
Issue of Publication
2
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
NY
Performing Organization
Columbia University New York, New York, New York
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