Health effects associated with occupational exposure to 2- diethylaminoethanol (100378) (DEAE) were reviewed as part of the agreement between NIOSH and the Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals to exchange information and expertise in the area of occupational safety and health to provide a scientific basis for the establishment of recommended occupational exposure limits. The occurrence, use, pharmacokinetics, toxicology, immunotoxicity and organ systems, mutagenic, genotoxic, carcinogenic, and reproductive effects of DEAE were reviewed. Three reports of clusters of cases associated with DEAE exposure were described, as were studies examining the dose response relationship of DEAE in humans and experimental animals. The author concludes that DEAE appears primarily to be an mucous membrane irritant in experimental animals, and limited data indicate it has similar properties in humans. A dose response relationship has been supported by findings in rats.