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Comparative cancer potency for silica from extrapolations of human and animal findings.

Authors
Goldsmith-DF; Ruble-RP; O'Klein-C
Source
Scand J Work, Environ & Health 1995 Sep; 21(Suppl 2):104-107
NIOSHTIC No.
00230587
Abstract
An analysis of the cancer risk associated with silica (14808607) dust exposure based on extrapolations of laboratory animal and epidemiological data was performed. Data were taken from three laboratory animal studies in which F344-rats inhaled Min-U-Sil-5 quartz or DQ12 quartz dusts for 24 months in which induction of lung tumors was the outcome of interest and two epidemiological studies conducted in South African gold miners and California diatomaceous- earth workers which found a clear dose response for lung cancer caused by silica dust exposure. Cancer potency slopes (CPSs) and inhalation cancer potency slopes (ICPs) were calculated from both the experimental animal and epidemiological data using the computer program GLOBAL 86, which fit linearized multistage models to the experimental data. The CPSs obtained by extrapolating the laboratory animal data varied from 0.08 to 20.89mg/kg/day. The corresponding ICPs after normalizing to an inhaled quartz concentration of 1 microgram per cubic meter (microg/m3) varied from 2.9x10(-5) to 6.0x10(-3)microg/m3. The CPSs obtained by extrapolating the epidemiological data varied from 3.09x10(-4) to 1.16x10(-2)mg/kg/day assuming a working lifetime of 40 years (yr). The corresponding ICPs varied from 1.83x10(-7) to 6.75x10(-5)microg/m3 for a working lifetime of 40yr after normalizing to an inhaled quartz concentration of 1microg/m3. The authors conclude that based on extrapolations of laboratory animal and epidemiological data, continuous inhalation of 1microg/m3 silica dust by humans will yield a lung cancer risk characterized by ICPs of 2.9x10(-5) to 6.0x10(-3) and 1.8x10(-7) to 6.8x10(-5), respectively.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Risk-analysis; Lung-cancer; Silica-dusts; Occupational-exposure; Computer-models; Epidemiology; In-vivo-studies; Laboratory-animals; Inhalation-studies
Contact
Internal Medicine University of California Internal Medicine Davis, CA 95616
CODEN
SWEHDO
CAS No.
14808-60-7
Publication Date
19950901
Document Type
Journal Article
Funding Amount
300972
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002726
ISSN
0355-3140
Priority Area
Pulmonary-system-disorders
Source Name
Scandinavian Journal of Work, Environment and Health
State
CA; FL
Performing Organization
University of California Davis, Davis, California
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