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Chronic neurologic sequelae to cholinesterase inhibition among agricultural pesticide applicators.

Authors
Ames-RG; Steenland-K; Jenkins-B; Chrislip-D; Russo-J
Source
Arch Environ Health 1995 Nov; 50(6):440-444
NIOSHTIC No.
00230076
Abstract
Neurobehavioral tests, nerve conduction tests, vibrotactile sensitivity tests, a postural sway test, and a clinical examination were used to investigate possible neurologic sequelae of exposure to cholinesterase inhibiting pesticides in 45 male pesticide applicators in California. The subjects were identified from records of the California medical supervision program and from laboratories certified for medical monitoring. All 45 subjects had a prior history of documented cholinesterase inhibition below worker removal thresholds, but without frank poisoning. Ninety male subjects without past cholinesterase inhibition formed the comparison group. Of the 27 neurologic measures, only one (serial digit performance) was statistically significant; prior cholinesterase inhibition was associated with enhanced performance on this test. According to the authors, these results indicated that preventing acute organophosphate poisoning also prevents neurologic sequelae.
Keywords
NIOSH-Author; Occupational-exposure; Cholinesterase-inhibitors; Chronic-toxicity; Neurotoxic-effects; Humans; Agricultural-workers; Neuromotor-function
CODEN
AEHLAU
Publication Date
19951101
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0003-9896
Priority Area
Neurotoxic-effects
Source Name
Archives of Environmental Health
State
CA
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