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Occupational Neuropathies due to Industrial Chemicals.

Authors
Abou-Donia-MB
Source
Department of Pharmacology, School of Medicine, Duke University, Durham, North Carolina 1994 Feb:3 pages
Link
NIOSHTIC No.
00228699
Abstract
A grant report on the development of biomarkers for exposure to the neurotoxic industrial chemicals n-hexane (110543) and carbon- disulfide (75150) was presented. A list of publications, including journal articles, a book chapter and abstracts generated by the grant was provided. The significant findings, usefulness of the findings and the relationship of the publications to the project were briefly discussed. Serum bound pyrroles were found to be unsuitable biomarkers for 2,5-hexanedione (110134) (2,5-HD). Antibodies to bovine serum albumen (BSA) pyrrole derivatives reacted to hair protein bound pyrroles from 2,5-HD treated rats. The advantages of using hair protein bound pyrrole adducts as biomarkers for 2,5-HD included the ready availability, accumulating properties and slow biological turnover of hair cells. Polyclonal antibodies to BSA pyrrole derivatives of 2,5-HD reacted with protein bound pyrrole compounds in intact and solubilized hair from 2,5-HD treated rats. Urinary 2,5-HD pyrrole derivatives were also being studied as biomarkers for 2,5-HD and n-hexane in treated rats. The author concludes that estimates of the duration and level of exposure from the analysis of hair could be used to correlate exposure with neurotoxic effects.
Keywords
NIOSH-Grant; Neurotoxic-effects; Chronic-exposure; In-vivo-studies; Laboratory-animals; Biological-monitoring; Analytical-methods;
Contact
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
CAS No.
110-54-3; 75-15-0; 110-13-4;
Publication Date
19940201
Document Type
Final Grant Report;
Funding Amount
1567389.00
Funding Type
Grant;
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00823
NIOSH Division
OEP
Priority Area
Neurotoxic Disorders; Neurotoxic-effects;
Source Name
Department of Pharmacology, School of Medicine, Duke University, Durham, North Carolina
State
NC;
Performing Organization
Duke University, Durham, North Carolina
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