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Dose-response assessment issues in occupational mortality studies.

Authors
Hertz-Picciotto-I; Lee-JT; Arrighi-HM
Source
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1995 Feb; :1-24
Link
NIOSHTIC No.
00228284
Abstract
This project examined absenteeism as a surrogate for ill health and its usefulness in the context of the differential survival problem. The data came from an occupational cohort study of arsenic (7440382) and lung cancer. The cohort consisted of all white male workers employed for 1 year or more between 1940 and 1964 at a copper smelter in Tacoma, Washington. After controlling for the level of current exposure, age at hire and year at hire, the risk of having a 30 day or longer absence was generally higher with increased level of cumulative exposure. In contrast, current exposure level shows an inverse relationship with absence. The mortality analysis suggests that a recent absence of more than 30 days was associated with a higher risk of death from respiratory cancer among employees exposed to arsenic. The authors caution that information on absenteeism without knowledge of the reasons for the absence is not in and of itself useful in such studies.
Keywords
NIOSH-Grant; Grants-other; Mortality-surveys; Cancer-rates; Carcinogens; Worker-health; Epidemiology; Lung-cancer; Respiratory-system-disorders
Contact
Epidemiology Univ of North Carolina Cb#7400 Mcgavran Greenberg HAl Chapel Hill, NC 27599-7400
CAS No.
7440-38-2
Publication Date
19950201
Document Type
Final Grant Report
Funding Amount
19363
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
PB95-269908
NTIS Price
A03
Identifying No.
Grant-Number-R03-OH-02971
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
State
WA; NC
Performing Organization
University of North Carolina Chapel Hill, Chapel Hill, North Carolina
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