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Transcranial Doppler sonography: a new noninvasive method for measuring toxicant-induced alterations in cerebral blood flow.

Authors
Drues-ME; Hopper-D
Source
Department of Biomedical Engineering, College of Veterinary Medicine Iowa State University, Ames, Iowa 1994 Jun; :1-11
Link
NIOSHTIC No.
00228282
Abstract
The use of transcranial doppler (TCD) sonography as a screening procedure to detect changes in cerebral blood flow after exposure to a toxicant was evaluated using an animal model. Technical grade deltamethrin (52918635) was administered to 12 anesthetized greyhound-dogs via injection in a cannula implanted into the carotid artery. Following exposure to 0.17 and 0.34mg/kg deltamethrin, a significant increase in mean blood flow velocity was observed in the middle cerebral artery. For both dose levels, the concentration of deltamethrin rose to a peak of 2.3 and 4.4 parts per million (ppm), respectively, at 5 minutes post exposure. The simultaneous occurrence of a peak in the concentration of blood deltamethrin and a peak in the mean cerebral blood flow further supports the relationship between the exposure to deltamethrin and the increase in cerebral blood flow. The authors conclude that TCD can be used successfully to measure cerebral blood flow using an animal model. TCD is able to detect short duration changes in cerebral blood flow, and may hold promise as a cost efficient and noninvasive means to assess cerebral flow as part of an overall chemical toxicity screening process.
Keywords
NIOSH-Grant; Grants-other; Cardiovascular-function; Circulatory-system; Insecticides; Laboratory-animals; Cerebrovascular-system
Contact
Biomedical Engineering Iowa State University 1146 Veterinary Medicine Ames, IA 50011
CAS No.
52918-63-5
Publication Date
19940611
Document Type
Final Grant Report
Funding Amount
32512
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
PB95-269924
NTIS Price
A03
Identifying No.
Grant-Number-R03-OH-02932
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Department of Biomedical Engineering, College of Veterinary Medicine Iowa State University, Ames, Iowa
State
IA
Performing Organization
Iowa State University of Science & Tech, Ames, Iowa
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