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Cumulative trauma disorder: skeletal muscle dysfunction.

Authors
Stauber-WT
Source
Department of Physiology, West Virginia University, Morgantown, West Virginia 1995 Mar; :1-10
Link
NIOSHTIC No.
00228277
Abstract
Experiments were designed to develop a reproducible technique for producing chronic strain injury to rat skeletal muscles as a model for cumulative trauma disorder (CTD), and to measure the functional outcome of repeated microtrauma in order to develop strategies and programs for its prevention. A dynamometer was designed and built to control the velocity and range of movement of the rat foot during a strain overload and test the functional outcome in terms of muscle strength, endurance, and stiffness in-vivo. Changes in the extracellular matrix and sarcolemma of skeletal muscles which could result in muscle pathology or adaptation were measured. Cumulative microtrauma was administered three times a week for 4 weeks to one leg of female rats. Muscles became myopathic after 1 month of exposure to repeated strains. The appearance of muscle pathology was related to the strain rate. Repeated high velocity strains were accompanied by myofiber heterogeneity and apparent fibrosis while low velocity strains produced muscle hypertrophy and positive adaptations. These two responses were noted in muscles commonly recruited for low level endurance activity. The authors conclude that appropriate rest periods are important for recovery from metabolic fatigue and repair of tissue damage.
Keywords
NIOSH-Grant; Musculoskeletal-system-disorders; Muscle-function; Repetitive-work; Laboratory-animals; Cumulative-trauma-disorders
Contact
Physiology West Virginia University 3051 Health Sciences North Morgantown, WV 26506
Publication Date
19950306
Document Type
Final Grant Report
Funding Amount
141085
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
PB95-269957
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-002918
NIOSH Division
OEP
Source Name
Department of Physiology, West Virginia University, Morgantown, West Virginia
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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