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Influence of particulates on occupational lung disease.

Authors
Warshawsky-D; Radike-M; Talaska-G; Miller-M
Source
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 1994 Jun; :1-34
Link
NIOSHTIC No.
00228266
Abstract
The ability of alveolar macrophages (AM) to phagocytize uncoated and benzo(a)pyrene (50328) (BaP) coated particulates was investigated. AM from male Syrian-golden-hamsters and Sprague-Dawley-rats were used. Particulates included crystalline-silica (14808607); precipitated, gelled, and fumed amorphous-silica (7631869); ferric- oxide (1309371); and aluminum-oxide (1344281). All forms of amorphous silica had smaller particle sizes and were cytotoxic, suggesting that more of the dose for the amorphous silicas entered the AM. Toxicity also appeared related to the surface properties, with those particles having more silanol groups being more cytotoxic. These same properties were important in the metabolic activation of BaP by AM. At a similar dose of BaP and particle, all of the BaP coated particles produced more BaP dihydrodiols than BaP alone. AM exposed to particles coated with BaP responded differently than either BaP or particles alone at noncytotoxic doses. For metabolism, DNA binding and cytotoxicity parameters, the surface area of the particle appeared to play a major role.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Pyrenes; Mineral-dusts; Respiratory-system-disorders; Lung-disease; Cell-cultures; Alveolar-cells; Polycyclic-aromatic-hydrocarbons
Contact
Environmental Health University of Cincinnati 3223 Eden Ave - M L #56 Cincinnati, OH 45267-0056
CAS No.
50-32-8; 14808-60-7; 7631-86-9; 1309-37-1; 1344-28-1;
Publication Date
19940630
Document Type
Final Grant Report
Funding Amount
479651
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
PB95-267878
NTIS Price
A04
Identifying No.
Grant-Number-R01-OH-02277
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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