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Scientific and ethical aspects of genetic screening of workers for cancer risk: The case of the n-acetyltransferase phenotype.

Authors
Vineis-P; Schulte-PA
Source
J Clin Epidemiol 1995 Feb; 48(2):189-197
NIOSHTIC No.
00226578
Abstract
Scientific and ethical issues involved in the genetic screening of individuals with increased susceptibilities to developing occupationally related cancers were examined. Minimum scientific evidence required for the use of genetic screening tests were described. Difficulties associated with obtaining such minimum evidence were illustrated by examination of the genetic polymorphism associated with the activity of N-acetyltransferase, an enzyme associated with the activation and deactivation of carcinogenic arylamines, and the risk of bladder cancer among workers exposed to such chemicals. Drawbacks to the use of N-acetyltransferase polymorphism as a biological marker of susceptibility to cancer were discussed. These included unavoidable misclassifications resulting from poor correspondence between phenotype and genotype or intraindividual phenotype variability, variability in the data linking specific N-acetyltransferase polymorphisms with cancer risk dependent upon exposure and population, violation of the autonomy of workers, ethical considerations, and the potential for employment restrictions based upon prejudices such as gender, race, or ethnic group that may be associated with this polymorphism.
Keywords
NIOSH-Author; Genetic-factors; Heredity; Occupational-exposure; Medical-screening; Screening-methods; Bladder-cancer
CODEN
JCEPEE
Publication Date
19950201
Document Type
Journal Article
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0895-4356
NIOSH Division
DSHEFS
Source Name
Journal of Clinical Epidemiology
State
OH
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