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Hydroxyl radical generation by coal mine dust: possible implication to coal workers' pneumoconiosis (CWP).

Authors
Dalal-NS; Newman-J; Pack-D; Leonard-S; Vallyathan-V
Source
Free Radic Biol Med 1995 Jan; 18(1):11-20
NIOSHTIC No.
00226156
Abstract
The potential role of hydroxyl radical generation by bituminous coal mine dust in the development of coal workers' pneumoconiosis (CWP) was examined. The dusts chosen for study represented two geographic areas with a diverse prevalence of CWP. Electron spin resonance was used in conjunction with spin trapping techniques to measure the generation of hydroxyl radicals from hydrogen-peroxide in the presence of the dust samples. The hydroxyl radical spin trap molecule was 5,5-dimethyl-1-pyrroline-N-oxide. The coal mine dust samples all generated varying levels of hydroxyl radicals from hydrogen-peroxide. The inclusion of free radical scavengers and metal ion chelators affected the amount of hydroxyl radicals generated; while EDTA and diethylenetriaminepentaacetic-acid enhanced hydroxyl radical generation, catalase and deferoxamine produced almost total inhibition and superoxide-dismutase produced partial inhibition. Surface iron (7439896) content of coal mine dusts was positively correlated with hydroxyl radical generating potential and potential to induce lipid peroxidation. The authors conclude that these findings point to a dominant role of the Fenton reaction in the generation of hydroxyl radicals from hydrogen- peroxide; the concentration of surface iron in coal mine dusts appears to be involved in the generation of hydroxyl radicals and play an important role in the development of CWP.
Keywords
NIOSH-Author; Occupational-exposure; Coal-workers; Coal-dust; Free-radicals; Coal-workers-pneumoconiosis; Dust-exposure; Free-radical-generation; Hydroxyl-groups; In-vitro-studies
CODEN
FRBMEH
CAS No.
7439-89-6
Publication Date
19950101
Document Type
Journal Article
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0891-5849
NIOSH Division
DRDS
Source Name
Free Radical Biology and Medicine
State
WV
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