Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

NIOH and NIOSH basis for an occupational health standard. 2-Ethyl-2- hydroxymethyl-1,3-propanediol.

Authors
Walinder-R
Source
NIOSH 1994 Dec; :1-20
NIOSHTIC No.
00225893
Abstract
The uses, physical properties, chemical properties and health effects of exposure to 2-ethyl-2-hydroxymethyl-1,3-propanediol (77996) (trimethylolpropane) were reviewed as a basis for the development of occupational health standards by NIOSH and the Swedish National Institute of Occupational Health (NIOH). Trimethylolpropane has been used in the production of polyurethanes, polyester resins, alkyd coatings and acrylates. It has been found in photocurable coatings, paints, varnishes and dental sealants. Animal testing revealed low levels of toxicity by oral, inhalation and dermal exposure. The oral median lethal dose (LD50) in rats was about 14 grams per kilogram. Signs of acute intoxication included depression of the central nervous system and damage to the liver and kidneys. The dermal LD50 in rabbits was greater than 10 grams/kilogram. Mild irritative dermal effects have been noted in animals, but no convincing evidence of irritation has been found in humans. Epidemiological studies or case reports of workers exposed have not been found. No studies on carcinogenicity were available. Limited in-vitro studies did not show any signs of genotoxicity.
Keywords
Laboratory-animals; Propanes; Toxic-effects; Comparative-toxicology; Neurotoxic-effects; Genotoxic-effects; In-vitro-studies; In-vivo-studies
CAS No.
77-99-6;
Publication Date
19941201
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1995
NTIS Accession No.
PB95-219598
NTIS Price
A03
Identifying No.
(NIOSH) 95-100
Source Name
National Institute for Occupational Safety and Health
State
OH
TOP