Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Physicochemical Properties and Membranolytic Activities of the Titanium Dioxide Polymorphs Compared with Those of Quartz.

Authors
Nolan-RP; Langer-AM; Herson-GB
Source
Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke, Proceedings of an International Symposium/Workshop, Seattle, Washington, April 10-14, 1988 1989:391-419
Link
NIOSHTIC No.
00225033
Abstract
A comparative study was conducted on the physicochemical properties and membranolytic activities of titanium-dioxide (13463677) (TiO2) polymorphs rutile (1317802) and anatase (1317700), and quartz (14808607). Three rutile specimens from Du Pont (R-100, R-900, and R-960), the rutile IOM-1, and an anatase sample were used for the study and compared with three quartz specimens (DQ12, F600, and Min- U-Sil). Particle characterization was performed by optical microscopy, size distribution measurements, and X-ray diffraction analysis. All synthetic TiO2 were in the respirable size range as revealed by particle size distribution measurements. Specimens were subjected to a human erythrocyte hemolytic model for a quantitative determination of their membranolytic potential. Determinations of hydrogen bonding to 2-poly(vinylpyridine-N-oxide) (2-PVPNO) were also made. All the Du Pont specimens were found to be membranolytically active and inhibited by 2-PVPNO. The anatase and rutile IOM-1 were found to be inert. Heating for 6 hours up to 600 degrees-C markedly decreased the membranolytic potential of the TiO2 samples. Quartz samples with a finer size distribution bound more 2- PVPNO, which also inhibited their membranolytic potential. Heating of the quartz samples only reduced their membranolytic abilities slightly. The authors conclude that such results may explain the fundamental mechanisms of interaction between respirable particles and biological systems.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Respirable-dust; Quartz-dust; Hemolysis; Physical-chemistry; Erythrocytes; Cell-damage; Mineral-dusts;
Contact
Medicine MT Sinai School of Medicine 1 Gustave Levy Place New York, N Y 10029
CAS No.
13463-67-7; 1317-80-2; 1317-70-0; 14808-60-7;
Publication Date
19890101
Document Type
Conference/Symposia Proceedings;
Editors
Wehner-AP;
Funding Amount
19495.00
Funding Type
Grant;
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-01905
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Source Name
Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke, Proceedings of an International Symposium/Workshop, Seattle, Washington, April 10-14, 1988
State
OH; WA; NY;
Performing Organization
Mount Sinai School of Medicine, New York, New York
TOP