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The relationship between bone lead and hemoglobin.

Authors
Hu-H; Watanabe-H; Payton-M; Korrick-S; Rotnitzky-A
Source
JAMA J Am Med Assoc 1994 Nov; 272(19):1512-1517
NIOSHTIC No.
00224457
Abstract
A cross sectional investigation was conducted in which blood lead (7439921) and bone lead levels among workers with only moderate lead exposure histories were related to blood pressure and indicators of renal function and hematologic status. The 119 study subjects were members of the construction trade union involved in carpentry, demolition and other construction activities. In-vivo bone lead measurements were made using K-X-ray fluorescence. Blood pressure was measured, and blood samples were analyzed for blood lead, hemoglobin, hematocrit, serum uric-acid, and serum creatinine. Bone lead levels were low and not correlated with either hemoglobin or hematocrit. An increase in patella bone lead levels from the lowest to highest quintile in this study population was associated with a decrease in hemoglobin and hematocrit of 11 grams/liter and 0.03, respectively. The authors conclude that this is the first epidemiological study to suggest that bone lead exerts subclinical toxicity in a population of apparently normal workers with low blood lead levels.
Keywords
NIOSH-Publication; NIOSH-Grant; Training; Blood-analysis; Lead-poisoning; Kidney-damage; Heavy-metal-poisoning; Epidemiology; Risk-factors; Construction-workers; Blood-pressure; Body-burden
Contact
Environmental Sci & Physiology, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
CODEN
JAMAAP
CAS No.
7439-92-1
Publication Date
19941116
Document Type
Journal Article
Funding Amount
1420712
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T15-OH-007096; Grant-Number-T42-OH-007096
Issue of Publication
19
ISSN
0098-7484
Priority Area
Training
Source Name
Journal of the American Medical Association
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
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