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Antigen-specific stimulation of histamine releasing factors in diisocyanate-induced occupational asthma.

Authors
Herd-ZL; Bernstein-DI
Source
Am J Respir Crit Care Med 1994 Oct; 150(4):988-994
NIOSHTIC No.
00223883
Abstract
A study was conducted on the production of antigen specific mononuclear cell derived histamine releasing factor (HRF) following exposure to diisocyanates. HRF production was assessed in blood cells obtained from methylene-diphenyldiisocyanate (MDI) exposed workers with confirmed occupational asthma (OA), those with unconfirmed OA, and asymptomatic workers. No significant differences were seen between subject groups in the HRF activity in peripheral blood monocyte culture supernatants. Antigen specific stimulation of HRF production was seen in seven of eight subjects with confirmed OA compared with no subjects in the other exposed groups. Specific immunoglobulin-E and immunoglobulin-G (IgG) antibodies were seen in two of nine asymptomatic and four of 11 symptomatic workers and one of nine asymptomatic and eight of 11 symptomatic workers, respectively. Associations were demonstrated between the presence of antigen specific HRF activity enhancement and confirmed OA as well as between the presence of specific IgG antibodies against diisocyanates and a positive history of OA. An analysis examining cellular sources of diisocyanate stimulated HRF indicated that lymphocytes and adherent cells were the major sources of spontaneous and antigen stimulated HRF. The authors conclude that antigen specific HRF is a useful biomarker for occupational asthma induced by exposure to diisocyanates.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Cyanates; Immune-reaction; Bronchial-asthma; Occupational-exposure; Occupational-medicine; Antibody-response
Contact
Internal Medicine University of Cincinnati Med C 231 Bethesda Ave. Cincinnati, Ohio 45267-0563
CODEN
AJCMED
Publication Date
19941001
Document Type
Journal Article
Funding Amount
97200.00
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00073
Issue of Publication
4
ISSN
1073-449X
Priority Area
Pulmonary-system-disorders
Source Name
American Journal of Respiratory and Critical Care Medicine
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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