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Dose-dependent tolerance to ozone. III. Elevation of intracellular Clara cell 10-kDa protein in central acini of rats exposed for 20 months.

Authors
Dodge-DE; Rucker-RB; Pinkerton-KE; Haselton-CJ; Plopper-CG
Source
Toxicol Appl Pharmacol 1994 Jul; 127(1):109-123
NIOSHTIC No.
00223619
Abstract
The regional restructuring of the central acinus in rats following long term exposure to ozone (10028156) was examined, and factors, including Clara cell 10 kilodalton protein (CC10), that may make some target cell populations more resistant to injury, were identified. Fisher-344-rats were exposed to either 0.12 or 1.00 parts per million (ppm) ozone or filtered air (control group) for 6 hours/day, 5 days/week for 20 months. Changes in CC10 protein abundance in the centriacinar region were then examined. The centriacini of rat lungs in the low ozone (0.12ppm) exposure group were indistinguishable from control lung centriacini. CC10 content was also similar between the two groups. Exposure to a high level (1.00ppm) of ozone resulted in the appearance of respiratory bronchioles containing CC10 in the nonciliated epithelium and increases in the following: the number of secretory granules per cell and in amount and density of granule based CC10; proportion of CC10 per nonciliated cell; proportion of nonciliated cells in terminal bronchioles; and total amount of CC10 stored in the epithelium. The authors conclude that rats adapt to ozone exposure, at least in part, with an increase in CC10 in the central acini epithelium. This increase is caused by several factors, including increased concentration and cellular abundance of CC10 in granules and an increased mass of nonciliated secretory cells.
Keywords
Laboratory-animals; Cytotoxic-effects; Cell-damage; Protein-chemistry; Protein-synthesis; Chronic-exposure; Toxic-gases; Inhalation-studies
CODEN
TXAPA9
CAS No.
10028156
Publication Date
19940701
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
1
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
CA
Performing Organization
University of California - Davis
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