Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis.
Smith-CM; Kelsey-KT; Wiencke-JK; Leyden-K; Levin-S; Christiani-DC
Cancer Epidemiol Biomark Prev 1994 Sep; 3(6):471-477
A study was conducted on genetic determinants of susceptibility to the development of asbestos (1332214) related pulmonary disease. The presence of asbestos pulmonary disease, degree of asbestos exposure, and the presence of the gene encoding for glutathione-S- transferase class-mu (GSTM-1) were assessed in a cohort consisting of members of the United Brotherhood of Carpenters and Joiners of America. Radiographic evidence of asbestos related pulmonary disease was seen in 12.2% of the 658 workers examined. The percentage of workers with pulmonary disease that were GSTM-1 negative was significantly higher than the percentage of workers without radiographic evidence of asbestos related disease. A multivariate analysis examining the effects of several other variables on the development of asbestos related pulmonary disease demonstrated that smoking, time working as a carpenter, and prior employment in construction all contributed significantly to the prevalence of radiographic abnormalities. Stepwise logistic regression analysis performed by smoking status demonstrated that for those who never smoked only genotype was significantly associated with radiographic abnormalities. The authors conclude that the presence or absence of the GSTM-1 gene appears to contribute to susceptibility to asbestos induced pulmonary disease.
NIOSH-Publication; NIOSH-Grant; Cancer; Genetic-factors; Heredity; Asbestos-workers; Asbestosis; Oxidative-enzymes; Cigarette-smoking; Pulmonary-system-disorders
Environmental Health Harvard School of Public Hlth 665 Huntington Avenue Boston, MA 02115
Cancer Epidemiology, Biomarkers & Prevention
Harvard University, Boston, Massachusetts