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A meta-analysis of colorectal cancer and asbestos exposure.

Authors
Homa-DM; Garabrant-DH; Gillespie-BW
Source
Am J Epidemiol 1994 Jun; 139(12):1210-1222
NIOSHTIC No.
00222540
Abstract
A meta analysis of asbestos (1332214) exposure and colorectal cancer mortality was presented in which asbestos type and dust levels were investigated as direct estimators of asbestos exposure. Lung cancer mortality and the proportion of deaths due to mesothelioma were investigated as proxy estimators of asbestos exposure. Published reports of 20 asbestos exposed cohorts formed the basis for this study. An elevated standard mortality ratio (SMR) was determined in cohorts exposed to amphibole asbestos but not in cohorts exposed to serpentine (79617962) asbestos fibers or in cohorts exposed to both serpentine and amphibole asbestos. Cohorts which had a lung cancer standard mortality ratio greater than 2.00 had a summary SMR of 1.51 and cohorts in which more than 1% of all deaths were attributed to mesothelioma had a summary SMR of 1.24. No clear correlation was found between lung cancer mortality and colorectal cancer mortality after stratifying the cohorts based on mortality due to all cancers excluding those known or suspected to be associated with asbestos exposure. There was a possibility noted that amphibole asbestos exposure may be associated with colorectal cancer, but these findings may reflect an artifact of miscertification of the cause of death.
Keywords
NIOSH-Publication; NIOSH-Grant; Training; Epidemiology; Mortality-surveys; Cancer-rates; Risk-factors; Respiratory-system-disorders; Asbestos-fibers; Fibrous-bodies; Gastrointestinal-system-disorders; Author Keywords: asbestos; colonic neoplasms; meta-analysis; occupational diseases
Contact
Industrial & Operations Engr University of Michigan 2254 G G Brown Laboratory Ann Arbor, Mich 48109
CODEN
AJEPAS
CAS No.
1332-21-4; 79617-96-2
Publication Date
19940615
Document Type
Journal Article
Funding Amount
5308504.00
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T15-OH-07207
Issue of Publication
12
ISSN
0002-9262
Priority Area
Respiratory-system-disorders
Source Name
American Journal of Epidemiology
State
MI
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
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