Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Activation of complement by silage.

Authors
Olenchock-SA; May-JJ; Pratt-DS; Lewis-DM; Mull-JC; Stallones-L
Source
Principles of health and safety in agriculture. Dosman JA, Cockcroft DW, eds., Boca Raton, FL: CRC Press, Inc., 1989 Oct; :116-118
Link
NIOSHTIC No.
00222436
Abstract
A study was conducted on the interaction between silage and human serum complement in-vitro and in-vivo. Four silage samples were reacted with pooled normal human serum in-vitro. A dose dependent consumption of complement component C3 was seen using extracts from each of the four silage samples tested. There were differences between the samples in the degree of induced complement activity. A correlation was seen between the endotoxin levels in the silage extracts and their complement fixing abilities. All of the extracts were unable to activate complement when the human sera were incubated with EDTA prior to addition of the silage. Pretreatment of the sera with EGTA was not effective in preventing the activation of complement by the samples. Nonsignificant decreases in serum levels of complement components C3 and C4 were seen between blood samples obtained before and after silage dust exposures in nine silo workers along with significant decreases in serum C4 levels in three of the exposed workers who became ill after the exposure.
Keywords
Organic-dusts; Grain-dusts; Toxic-effects; Dust-exposure; Agricultural-workers; Biological-effects; In-vitro-study; In-vivo-study; Immune-system
Publication Date
19891031
Document Type
Book or book chapter
Editors
Dosman-JA; Cockcroft-DW
Fiscal Year
1990
NTIS Accession No.
NTIS Price
ISBN No.
9780849301605
Source Name
Principles of health and safety in agriculture
State
FL
TOP