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Silicosis.

Authors
Balaan-MR; Banks-DE
Source
Environmental and Occupational Medicine, Second Edition 1992 Jan; :345-358
Link
NIOSHTIC No.
00222083
Abstract
Silicon (7440213) induced pulmonary disease was discussed in this review. Occupations including sandblasting, mining or tunneling, milling, pottery, glassmaking, foundry work, quarry work, and abrasive work have been found to pose a high risk to workers for silicosis. Pathological changes in the lungs of patients with chronic silicosis have included fibrosis of the visceral pleura and hyalinized intrapulmonary nodules along with the presence of birefringent material in the periphery. Progressive massive fibrotic lesions have resulted from the coalescence of the silicotic nodules. Acute silicosis has been distinguished by the presence of proteinaceous material in the alveoli along with hypertrophic type- II pneumocytes and a minimal amount of fibrosis. Studies have suggested that the fibrogenic effect of silica (14808607) may be due to the release of inflammatory mediators by silica activated alveolar macrophages. The clinical presentation, diagnosis, and natural history of silicosis were described and discussed.
Keywords
NIOSH-Cooperative-Agreement; Silicon-compounds; Silica-dusts; Silicate-miners; Pulmonary-system-disorders; Physiopathology; Occupational-exposure; Risk-factors
CAS No.
7440-21-3; 14808-60-7
Publication Date
19920101
Document Type
Book or book chapter
Editors
Rom-WN
Funding Amount
2937066
Funding Type
Cooperative Agreement
Fiscal Year
1992
NTIS Accession No.
NTIS Price
ISBN No.
0316755672
Identifying No.
Cooperative-Agreement-Number-U60-CCU-306149
NIOSH Division
OECSP; DRDS
Priority Area
Pulmonary-system-disorders
Source Name
Environmental and Occupational Medicine, Second Edition
State
MA; WV; DC
Performing Organization
Center to Protect Workers' Rights
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