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Pulmonary Response of Guinea Pigs to Inhalation of Purified Cotton Bract Extract.

Authors
Castranova-V; Robinson-VA; Barger-MW; Siegel-PD; Judy-DJ; Schachter-EN; Frazer-DG
Source
1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee 1993:248-251
Link
NIOSHTIC No.
00221454
Abstract
The pulmonary responses of the guinea-pig animal model to inhalation of purified cotton bract extract which was free of endotoxin and chemotactic peptide were examined. These responses were compared to those induced by inhalation of a crude cotton dust extract which contained both endotoxin and chemotactic peptide. An aqueous extract of cotton bract was prepared which contained low endotoxin and nondetectable levels of n-formylmethionyl-leucyl-phenylalanine. Guinea-pigs were exposed for 3 hours to aerosols nebulized from a solution containing 30 milligrams of cotton bract extract per milliliter of sterile water. No changes in pulmonary parameters were noted at the lower two doses of purified cotton bract extract. At the highest dose level, however, increases were observed in breathing rate, macrophage superoxide release as well as bronchoalveolar lavage yield of total cells, red blood cells, lymphocytes, and granulocytes. The authors conclude that, although these pulmonary responses were qualitatively similar to those observed in guinea-pigs exposed to crude cotton dust extract, purified cotton bract extract exhibited somewhat lesser potency.
Keywords
Cotton-dust; Endotoxins; Plant-dusts; Respiratory-system-disorders; Laboratory-animals; Lung-cells; Pulmonary-function; Inhalation-studies;
Publication Date
19930101
Document Type
Conference/Symposia Proceedings;
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Priority Area
Respiratory-system-disorders
Source Name
1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee
State
LA; TN;
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