Occupational health and safety intervention studies published during 1988 to 1993 were reviewed, as were some pre1988 studies that addressed specific issues. Computerized databases accessed were NIOSHTIC, Psych-Abstracts, and the Wilson Social Science Index. The review focused on engineering interventions (ergonomics, sick building syndrome, keyboard adjustments, grocery store barriers, mechanical supports for construction workers, toilets and showers for patients, and engineering controls to reduce or eliminate exposure to hazards such as chemicals, body fluids, soap, contaminated needles, noise, heat, and nicotine); behavioral interventions (education, training, risk communication, and ergonomics and health and safety procedure compliance); administrative interventions (job rotation, line speed, work/rest schedules, work area monitoring, safety officers, job enlargement, preventive equipment, facility remodeling, and biological monitoring); and other interventions, with particular regard to job stress reduction. For each study, the theoretical basis, intervention duration, study design, subject selection, instrument reliability and validity, and statistical methods applied were assessed. The review suggested that overall, intervention research was useful in addressing occupational health and safety hazards, but that in view of methodological issues, the conditions under which the research were successful were not clear. Several areas for future research remained, and these were discussed. The importance of interdisciplinary teams was stressed.