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Screening for insecticide overexposure under field conditions: a reevaluation of the tintometric cholinesterase kit.

Authors
McConnell-R; Magnotti-R
Source
Am J Publ Health 1994 Mar; 84(3):479-481
NIOSHTIC No.
00220657
Abstract
The validity of a semiquantitative screening kit for measuring whole blood cholinesterase levels in persons exposed to organophosphate pesticides was evaluated. Blood was drawn from 79 male workers for analysis of both whole blood cholinesterase via the tintometric kit and erythrocyte cholinesterase via a reference assay. The workers were employed at rural landing strips and a large crop dusting airport in Nicaragua, and were considered to be highly exposed to organophosphate pesticides. While overall correlation between the kit and the reference assay was good, either sensitivity or specificity of the tintometric kit was less than 75% for each of the three critical tintometric categories commonly used to define the limit of normal (75%, 62.5%, and 50% of control activity). The tintometric tests proved to have a predictive value, either positive or negative, of less than 80%. The authors conclude that caution should be used in interpreting results of this biomarker of organophosphate exposure, particularly in the screening of populations with low prevalence of overexposure; accuracy may be compromised without appropriate validation and rigorous quality control measures.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Occupational-exposure; Screening-methods; Biological-monitoring; Agricultural-chemicals; Cholinesterase-inhibitors; Organo-phosphorus-pesticides; Humans;
Contact
Community Medicine Mount Sinai School of Medicine One Gustave L. Levy Place New York City, NY 10029-6754
CODEN
AJHEAA
Publication Date
19940301
Document Type
Journal Article
Funding Amount
161987
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000123
Issue of Publication
3
ISSN
0090-0036
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
American Journal of Public Health
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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