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National Institute for Occupational Safety and Health Occupational fiber exposures and lung disease research strategy.

Authors
NIOSH
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1993 Jul; :1-22
Link
NIOSHTIC No.
00219218
Abstract
Research needs and research strategies for identifying and preventing lung disease resulting from occupational fiber exposure were developed. The report established research priorities and described the various types of research on fibers, including asbestos (1332214). Research areas discussed included fiber characterization, fiber analysis, biological activity, mechanisms of disease, epidemiological investigations, and control methods. Within the area of biological activity and mechanisms of disease, topics included the need for dose response relationships, role of radicals in pathogenesis, animal short and long term exposure studies, in- vitro exposure studies, genotoxicity, and biomarkers. Epidemiological research areas considered included characterization of exposure, nonasbestiform fibers, mineral and synthetic fibers, pulmonary fibrosis and carcinogenesis, other neoplasms, updating studies, and biological markers. Control methods included substitution of materials, new or modified controls, development of new substitute products, and protective clothing. Research strategies discussed included the need for disease mechanism research, the role of epidemiological studies in assessing human risk, the role of in-vivo and in-vitro studies, integration of various studies, and research priorities.
Keywords
NIOSH-Author; Mineral-dusts; Fiber-deposition; Fibrous-bodies; Asbestos-fibers; Fibrous-dusts; Respiratory-system-disorders; Carcinogens; Laboratory-animals; Free-radicals; Inhalation-studies
CAS No.
1332-21-4
Publication Date
19930715
Document Type
Other
Fiscal Year
1993
NTIS Accession No.
PB94-173739
NTIS Price
A03
Source Name
National Institute for Occupational Safety and Health
State
OH
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