Re: lung cancer incidence among patients with beryllium disease.
Eisenbud-M; Steenland-K; Ward-E
J Natl Cancer Inst 1993 Oct; 85(20):1697-1699
In this letter to the editor and a reply, earlier reports of an excess of lung cancer occurring among patients with beryllium (7440406) disease were considered. Of the 689 patients in the study, 28 died of lung cancer that developed after entry into the registry. Of the 689 patients, 235 were suffering from acute beryllium disease and 17 of these died of lung cancer. All 17 of these patients had a history of employment at a facility in Lorain, Ohio, where the exposure levels were high. The Lorain facility had employed 61% of all patients who had acute beryllium disease reported to the registry. There may have been a confounding factor in the Lorain cohort which may have been cigarette smoking or another carcinogen. Exposure to workers has been reduced more than 100 fold below those that existed when the Lorain facility was in operation. In the response, the authors of the original study indicated that the sparse numbers make it difficult to draw any conclusions about lung cancer risk at Lorain versus the other facilities. The increased risk of lung cancer was not confined to the workers at the Lorain facility. Data were not adequate to develop lung cancer risk estimates by quantitative level of exposure.
NIOSH-Author; Risk-factors; Epidemiology; Occupational-exposure; Risk-analysis; Carcinogens; Cancer-rates; Mortality-data; Lung-cancer; Respiratory-system-disorders
Journal of the National Cancer Institute