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Sister-chromatid exchanges in lymphocytes are increased in relation to longitudinally measured occupational exposure to low concentrations of styrene.

Authors
Yager-JW; Paradisin-WM; Rappaport-SM
Source
Mutat Res 1993 Nov; 319(3):155-165
NIOSHTIC No.
00217675
Abstract
A study was conducted on the dose response relationship between styrene (100425) exposure and the induction of genotoxicity. Blood samples were obtained from workers in a boat manufacturing facility and the presence of sister chromatid exchanges and micronuclei in lymphocytes and styrene and styrene-glycol concentrations in the blood were determined. Occupational exposures to styrene were monitored as well over the course of 1 year. The highest exposure levels were seen in laminators, chopper gun operators, and mold repairers. Linear regression analyses demonstrated that the incidence of sister chromatid exchanges was significantly increased in cigarette smokers and in those exposed to a mean air concentration of styrene of 64.2mg/m3. It was estimated that about 25% of the variability in sister chromatid exchanges seen in this cohort could be accounted for by exposure to styrene and 62% by cigarette smoking. No effects of styrene exposure on the frequency of micronuclei were seen.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Genotoxic-effects; Occupational-exposure; Cigarette-smoking; Dose-response; Boat-manufacturing-industry; Author Keywords: Sister-chromatid exchange; SCE; Micronuclei; MN; Cytokinesis-block; Lymphocytes; Styrene; Low-level exposure; Longitudinal; Occupational exposure; Intra- and inter-individual MN; Gender; Age
Contact
Biomedical & Environ Hlth Scis University of California School of Public Health Berkeley, CA 94720
CODEN
MUREAV
CAS No.
100-42-5
Publication Date
19931101
Document Type
Journal Article
Funding Amount
838959
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02221
Issue of Publication
3
ISSN
0027-5107
Priority Area
Other Occupational Concerns
Source Name
Mutation Research
State
CA
Performing Organization
University of California Berkeley, Berkeley, California
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