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Exposure of rats to hyperoxia: alteration of lavagate parameters and macrophage function.

Authors
Dedhia-HV; Ma-JY; Vallyathan-V; Dalal-NS; Banks-D; Flink-EB; Billie-M; Barger-MW; Castranova-V
Source
J Toxicol Environ Health 1993 Sep; 40(1):1-13
NIOSHTIC No.
00217003
Abstract
A study was conducted on the pulmonary response of Sprague-Dawley- rats to exposure to hyperoxia. Animals were exposed to an atmosphere of 100% oxygen (7782447) for 64 hours and bronchoalveolar lavage fluid was obtained immediately after termination of the exposure. Decreases in the percentage of alveolar macrophages and increases in the percentages of red blood cells, neutrophils, and lymphocytes were seen following the exposure. In addition a significant increase was noted in the protein content of the lavage fluid. Hyperoxia induced a significant decrease in the ability of alveolar macrophages to secrete hydrogen-peroxide and produce oxygen radicals in response to stimulation by zymosan. A significant decrease was seen as well in the ability of the macrophages to exclude trypan-blue dye. The oxygen exposed macrophages had a greater chemiluminescence response to zymosan compared with controls, and lipid peroxidation in these cells was significantly increased as well.
Keywords
NIOSH-Author; Toxic-effects; Oxygen-toxicity; Lung-function; Alveolar-cells; Oxidative-processes; Laboratory-animals
CODEN
JTEHD6
CAS No.
7782-44-7
Publication Date
19930901
Document Type
Journal Article
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0098-4108
NIOSH Division
DRDS
Source Name
Journal of Toxicology and Environmental Health
State
WV
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