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NIOSH Testimony on a Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg3/4/Day by R. W. Niemeier, August 4, 1992.

Authors
NIOSH
Source
NIOSH 1992 Aug:3 pages
Link
NIOSHTIC No.
00216273
Abstract
This testimony summarized information and comments from NIOSH regarding the proposal for a unified animal to human scaling factor for carcinogen risk assessment. A scaling factor of body weight raised to the 3/4 power had been proposed. This factor would be adopted by the Environmental Protection Agency, the Food and Drug Administration, and the Consumer Product Safety Commission. The assumptions under which the scaling factor was established were discussed. The graphs contained in the draft report to illustrate the cross species scaling relationships should be labeled as theoretically expected relationships. Although the draft report made it very clear that case specific information is considered preferable to the use of the default scaling factor and that the development of case specific information is encouraged, the question of just how the case specific information should be used when it is available was left open. The question of pharmacodynamic differences between species in susceptibility to carcinogens was considered.
Keywords
NIOSH-Author; NIOSH-Testimony; Niemeier-R-W; Risk-analysis; Carcinogens; Laboratory-animals; Carcinogenesis; Comparative-toxicology;
Publication Date
19920804
Document Type
Testimony;
Fiscal Year
1992
NTIS Accession No.
PB94-117058
NTIS Price
A01
NIOSH Division
DSDTT;
Source Name
NIOSH, 3 pages, 1 reference
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