Biomarkers in occupational lung disease.
Sem Respir Med 1993 May; 14(3):167-180
The use of biomarkers in the study of occupational and environmental lung disorders was reviewed. Three types of biological markers, markers of exposure, markers of effect or response, and markers of susceptibility were discussed. Biomarkers that have been useful in exposure assessments for occupational lung disorders resulting from inhaled particles or fibers, such as bronchoalveolar lavage, magnetopneumography, electron microscopy, energy dispersive X-ray spectroscopy, and electron diffraction microscopy, were described. Other techniques such as measuring the formation of DNA and/or protein adducts and skin and serum immunologic tests have been used to assess exposure to inhaled soluble agents. Measurement of pulmonary capacity, examination of gross anatomy, and assessment of cellular measures of lung injury have been useful biomarkers of effect or response. The genotoxic effects of exposures have been evaluated by examining oncogene expression. Susceptibility biomarkers have been more difficult to identify than the other types of markers; however, studies have suggested associations between the level of ability to induce P450 enzymes and lung cancer, as well as the presence of atopy and a risk of occupational asthma.
NIOSH-Grant; Pulmonary-system-disorders; Occupational-exposure; Environmental-exposure; Toxic-effects; DNA-adducts; Genotoxic-effects; Lung-disorders; Bronchial-asthma; Immunological-tests
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
Seminars in Respiratory Medicine
University of Iowa, Iowa City, Iowa