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Case control study of cancer in synthetic rubber workers.

Authors
Matanoski-GM; Correa-Villasenor-A; Francis-M; Elliott-EA
Source
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 1993 May; :1-30
Link
NIOSHTIC No.
00215356
Abstract
A nested case/control study was conducted of gastrointestinal cancer in male workers from eight styrene-butadiene polymer manufacturing facilities in the United States and Canada to determine whether there was any association with exposures to styrene (100425) and butadiene (106990). A study on the association between hematologic neoplasms and exposure to butadiene and styrene was reexamined using different criteria for matching and exposure. Exposure levels for each job in the industry were developed, based on area and personal monitoring. The risk of lymphohematopoietic cancers was increased in the workers who had increased exposure to butadiene. Even using different methodologies such as choosing different types of controls, the risk of leukemia among these workers remained high. Among the leukemia cases, there was a higher than expected proportion of acute lymphocytic leukemia. Some of the odds ratios were high for butadiene and styrene associated with esophageal cancers, but the findings were not statistically significant. Also not significant was a suggestive trend for increasing odds ratios with increasing butadiene exposure for colorectal cancers. When short term workers were included, there was an increase in the all cause mortality, but no increase in standardized mortality ratios for cancer or circulatory diseases. Long term workers had higher risks for cancers of interest in this study than short term workers.
Keywords
NIOSH-Grant; Cancer; Leukemogenesis; Cancer-rates; Risk-factors; Mortality-surveys; Occupational-exposure; Epidemiology; Synthetic-rubber-manufacturing; Gastrointestinal-system-disorders
Contact
Epidemiology Johns Hopkins Universiyt 615 North Wolfe Street Baltimore, MD 21205
CAS No.
100-42-5; 106-99-0
Publication Date
19930520
Document Type
Final Grant Report
Funding Amount
652183
Funding Type
Grant
Fiscal Year
1993
NTIS Accession No.
PB93-236131
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-02730
NIOSH Division
OEP
Source Name
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland
State
ME; MD
Performing Organization
Johns Hopkins University, Baltimore, Maryland
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