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Chemical Hazards to Human Reproduction.

Authors
NIOSH
Source
Council on Environmental Quality, 1981 Jan:307 pages
Link
NIOSHTIC No.
00214871
Abstract
Chemical hazards to human reproduction were evaluated with emphasis on the nature and extent of reproductive toxicity, its causes, and its importance as a public health concern. The human reproductive system and its susceptibility to toxic chemicals were discussed, including prenatal susceptibility to chemical insult, susceptibility of male and female systems, and the relationship between sites of action and observable adverse outcomes. Sources of data on reproductive impairment in human populations were considered, including international surveys of vital statistics, surveillance and research studies, trends and patterns, and the extent of reproductive impairment in the United States. Drugs and other chemicals reported to affect reproductive function in humans were discussed. Experimental assays for the effects of chemicals on reproduction were described, including assays in humans, teratogenicity tests in mammals, three generation reproduction tests in mammals, and the dominant lethal assay in mammals. The concordance between reported effects in humans and measured effects in animals was discussed. Policy issues raised by this report were considered. The authors conclude that the relationship between exposure to chemicals and human reproductive impairment may be an important area of public health concern that deserves further scientific investigation and evaluation.
Keywords
Reproductive-hazards; Reproductive-effects; Toxic-effects; Teratogens; Epidemiology; Laboratory-animals; Environmental-exposure; Prenatal-exposure; In-utero-exposure; Reproductive-system-disorders;
Publication Date
19810101
Fiscal Year
1981
NTIS Accession No.
PB81-191041
NTIS Price
A15
Priority Area
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders;
Source Name
Council on Environmental Quality, 307 pages, 500 references
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