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A laboratory model of sick building syndrome.

Authors
Frank-R; Davidoff-LL; Guilarte-T; Paquette-N; Weinmann-G
Source
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 1992 Dec; :1-37
Link
NIOSHTIC No.
00214631
Abstract
The goal of this study was to develop a laboratory model of Sick Building Syndrome (SBS). Preliminary studies were conducted concerning the fractional uptake and excretion of volatile organic compounds (VOCs). Techniques were developed and tested for correlating the effects of VOCs on the composition of tear fluid and symptoms of eye irritation as eye irritation is a frequently reported symptom of SBS. Lactic-dehydrogenase, total proteins, and differential cell counts of polymorphonuclear leukocytes, macrophages, and epithelial cells were studied as markers in tear fluid. The effects of VOCs on the performance of neurobehavioral tasks were also investigated. Subjects were exposed to a total VOC concentration of 20mg/m3 or less in an exposure chamber, and administered cognitive tests, including a grammatical reasoning task and a switching direction task. The test/retest reliability of cerebral glucose metabolism measurements was established for a dual detector probe system for monitoring metabolism in the central nervous system.
Keywords
NIOSH-Grant; Psychological-disorders; Indoor-air-pollution; Organic-compounds; Closed-building-syndrome; Air-quality-monitoring; Eye-irritants; Eye-disorders; Respiratory-system-disorders; Neurotoxic-effects; Indoor-environmental-quality
Contact
Environmental Health Sciences Johns Hopkins University 615 North Wolfe Street Baltimore, MD 21205
Publication Date
19921218
Document Type
Final Grant Report
Funding Amount
20005
Funding Type
Grant
Fiscal Year
1993
NTIS Accession No.
PB93-217131
NTIS Price
A04
Identifying No.
Grant-Number-R03-OH-02856
NIOSH Division
OEP
Source Name
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland
State
MD
Performing Organization
Johns Hopkins University, Baltimore, Maryland
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