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Cytoskeletal proteins and axonal neuropathies.

Authors
Abou-Donia-MB; Lapadula-DM
Source
Comments Toxicol 1989 Jan; 3(5):427-444
Link
NIOSHTIC No.
00214031
Abstract
This review discussed neurofilamentous neuropathies and organophosphorus compound induced delayed neurotoxicity. A brief discussion was presented of the cytoskeletal proteins including microtubules, intermediate filaments, and microfilaments. The microfilaments are present in the peripheral areas in the axon and dendritic spines, usually in close association with plasma membrane. Microtubules are found in the cell center while neurofilaments may be centrally or peripherally located. The distribution of cytoskeletal proteins in peripheral nerves was discussed. Many of the most widely studied neurotoxicants produce a characteristic accumulation of neurofilaments. The accumulation may occur in the cell body, in the initial segment of the axon, or in the middle to terminal regions of the axon. At least five hypotheses have been proposed to account for the axonal accumulation of neurofilaments produced by these compounds. These included pyrrole formation, inhibition of glycolytic enzymes, neurofilament crosslinking, neurofilament phosphorylation, and diminished proteolysis.
Keywords
NIOSH-Grant; Neurotoxic-effects; Protein-chemistry; Protein-synthesis; Organo-phosphorus-compounds; Nervous-system-disorders;
Contact
Pharmacology Duke University Medical Center Box 3813 Durham, NC 27710
CODEN
COTXEI
Publication Date
19890101
Document Type
Journal Article;
Funding Amount
665055.00
Funding Type
Grant;
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02003
Issue of Publication
5
ISSN
0886-5140
Priority Area
Neurotoxic Disorders; Neurotoxic-effects;
Source Name
Comments on Modern Biology. Part B, Comments on Toxicology
State
NC;
Performing Organization
Duke University, Durham, North Carolina
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