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Rapid induction of thy-1 antigenic markers on keratinocytes and epidermal immune cells in the skin of mice following topical treatment with common preservatives used in topical medications and in foods.

Authors
Rheins-LA; Young-EM; Nordlund-ML; Berning-RB; Nordlund-JJ
Source
J Invest Dermatol 1987 Nov; 89(5):489-494
NIOSHTIC No.
00214011
Abstract
A study was conducted to determine whether topical application of certain compounds could change the density, function, and expression of Ia+ Langerhans cells (LC) or Thy-1+ dendritic epidermal cells (DEC) or cause increased expression of Ia and Thy-1 on keratinocytes. Butylated-hydroxytoluene (128370) (BHT) or butylated- hydroxyanisole (25013165) (BHA) was applied to the shaved back or dorsal surface of the ear of male DBA/2d-mice, C57BL/6b-mice, or Balb/C4-mice on days one through five. Skin biopsies were obtained on day six, for the population density of LC and Thy-1 DEC. BHT and BHA were shown to significantly increase the population density of Thy-1+ DEC within 5 days. No effect was noted on Ia+ cells. The authors suggest that the Thy-1 DEC cells may be more mobile and/or their surface markers may be readily expressed and not a slowly mobile population. These parasubstituted phenolic compounds appear to act like pertussis-toxin and induce Thy-1 and Ia+ expression in keratinocytes. No accompanying functional alterations were noted in the immune response to contact allergens.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Allergic-reactions; Skin-exposure; Food-additives; Laboratory-animals
Contact
Dermatology University of Cincinnati 231 Bethesda Avenue Cincinnati, OH 45267
CODEN
JIDEAE
CAS No.
128-37-0; 25013-16-5
Publication Date
19871101
Document Type
Journal Article
Funding Amount
434101
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002091
Issue of Publication
5
ISSN
0022-202X
Priority Area
Dermatitis
Source Name
Journal of Investigative Dermatology
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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