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The Significance of Inhibition of Nonspecific Esterases in the Development of Organophosphorus-Induced Delayed Neurotoxicity.

Authors
Abou-Donia-MB; Lapadula-DM; Carrington-CD; Nomeir-AA
Source
Cholinesterases: Fundamental and Applied Aspects 1984:447-461
Link
NIOSHTIC No.
00213965
Abstract
The effects of oral and dermal administration of S,S,S-tri-n-butyl- phosphorotrithioate (78488) (DEF) were investigated on specific enzymes in the nervous system. Laying leghorn-hens were treated with DEF, tri-o-cresyl-phosphate (78308), or parathion (56382). DEF was able to produce three toxic effects: acute cholinergic effect occurring shortly after exposure as the result of acetylcholinesterase (AChE) inhibition; late acute effect occurring 2 to 4 days after oral administration of large DEF doses which resulted from n-butyl-mercaptan toxicity and caused hematotoxicity, loss of appetite and weight, weakness, emaciation, paralysis, and death and was neither related to AChE inhibition or associated with histopathological changes in nerve tissues; and delayed neurotoxicity occurring 6 to 14 days after dermal application, causing axonal and myelin degeneration along with ataxia, paralysis, and death. While dermal dosing with DEF significantly inhibited brain neurotoxic esterase (NTE), oral administration did not inhibit NTE, and also failed to produce organophosphorus compound induced delayed neurotoxicity.
Keywords
NIOSH-Grant; Neurotoxic-effects; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Central-nervous-system; Agricultural-chemicals; Herbicides; Brain-damage; Defoliants; Plasticizers;
Contact
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
CAS No.
78-48-8; 78-30-8; 56-38-2;
Publication Date
19840101
Document Type
Book or book chapter;
Editors
Brzin-M; Barnard-EA; Sket-D;
Funding Amount
1567389.00
Funding Type
Grant;
Fiscal Year
1984
NTIS Accession No.
NTIS Price
ISBN No.
3110098733
Identifying No.
Grant-Number-R01-OH-00823
Priority Area
Neurotoxic Disorders; Neurotoxic-effects;
Source Name
Cholinesterases: Fundamental and Applied Aspects
State
NY; NC;
Performing Organization
Duke University, Durham, North Carolina
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