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Triphenyl Phosphite: A Type II Organophosphorus Compound-Induced Delayed Neurotoxic Agent.

Authors
Abou-Donia-MB
Source
Organophosphates: Chemistry, Fate, and Effects 1992:327-351
Link
NIOSHTIC No.
00213964
Abstract
The neurotoxicity of triphenyl-phosphite (101020) was studied. Following a brief discussion of phosphorus compounds and their chemical properties, including pentavalent and trivalent phosphorus containing compounds, specific attention was directed toward the action of organophosphorus esters. Acute toxicity is produced by these compounds through the inhibition of acetylcholinesterase (AChE), which is the enzyme responsible for hydrolyzing the neurotransmitter acetylcholine (ACh). Poisoning by organophosphorus compounds results in the accumulation of ACh in the central nervous system, creating tension, anxiety, restlessness, insomnia, headache, emotional instability, excessive dreaming, and nightmares. In addition to inhibiting AChE, some of these compounds produce a condition known as organophosphorus compound induced delayed neurotoxicity. Triaryl phosphites were reviewed with topics including acute convulsion action, in-vitro hydrolysis, differential neurotoxic actions of triphenyl phosphites resulting from differential routes of administration, neuropathological changes, the effect of age on sensitivity of chickens to triphenyl-phosphite induced delayed neurotoxicity, and the biochemical action.
Keywords
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neuropathy; Laboratory-animals; Agricultural-chemicals; Organo-phosphorus-compounds; Organo-phosphorus-pesticides;
Contact
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
CAS No.
101-02-0;
Publication Date
19920101
Document Type
Book or book chapter;
Editors
Chambers-JE; Levi-PE;
Funding Amount
1567389.00
Funding Type
Grant;
Fiscal Year
1992
NTIS Accession No.
NTIS Price
ISBN No.
0121673456
Identifying No.
Grant-Number-R01-OH-00823
Priority Area
Neurotoxic Disorders; Neurotoxic-effects;
Source Name
Organophosphates: Chemistry, Fate, and Effects
State
NC;
Performing Organization
Duke University, Durham, North Carolina
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