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Strategies for the treatment of pneumoconiosis.

Authors
Banks-DE; Cheng-YH; Weber-SL; Ma-JK
Source
Occup Med: State of the Art Rev 1993 Jan; 8(1):205-232
Link
NIOSHTIC No.
00213429
Abstract
Following a brief review of the pathogenesis of silicosis, this report considered important aspects of therapies for pneumoconiosis which have been tried. There has been an aggressive search for therapeutic agents and procedures in China for silicosis and coal workers' pneumoconiosis. Various treatments for silicosis and coal workers' pneumoconiosis were discussed, including protection of the alveolar macrophage from silica (14808607) toxicity by using an aluminum-citrate complex of poly-2-vinylpyridine-N-oxide or poly-4-vinylpyridine-N-oxide (PVNO); control of the immune and inflammatory response through use of immunosuppressive and corticosteroid therapies; control of fibroproliferative activity through the use of tetrandrine or xinin; prevention of associated disease through the use of antimycobacterial therapy and pneumococcal vaccine; the removal of dust, macrophage and cytokines through whole lung lavage; lung transplantation; and monoclonal antibody therapy.
Keywords
NIOSH-Publication; NIOSH-Cooperative-Agreement; Medical-treatment; Lung-disease; Respiratory-system-disorders; Lung-cells; Alveolar-cells; Coal-miners; Lung-fibrosis
CODEN
SAOME4
CAS No.
14808-60-7
Publication Date
19930101
Document Type
Journal Article
Editors
Banks-DE
Funding Amount
2937066
Funding Type
Cooperative Agreement
Fiscal Year
1993
NTIS Accession No.
NTIS Price
ISBN No.
9781560531296
Identifying No.
Cooperative-Agreement-Number-U60-CCU-306149
Issue of Publication
1
ISSN
0885-114X
Priority Area
Pulmonary-system-disorders
Source Name
Occupational Medicine: State of the Art Reviews. The Mining Industry
State
DC
Performing Organization
Center to Protect Workers' Rights
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