Possible health hazards resulting from occupational exposure to ethyl-ether (60297) were reviewed and discussed. Topics included physical properties, chemical properties, industrial uses, occupational exposures, toxicokinetics, acute toxicity, chronic toxicity, organ system effects, immunotoxicity, mutagenicity, genotoxicity, carcinogenicity, reproductive toxicity, dose/response relationships, and research needs. Studies have indicated that the acute and chronic toxicity of the ethyl-ether is low. Inhalation and skin absorption have been the most important routes of occupational exposure. Upper respiratory tract irritation is the critical effect which should be taken into consideration when setting an occupational exposure limit. Nasal irritation has been reported at 200 parts per million. Chronic exposure to low concentrations of ethyl-ether in air may produce central nervous system symptoms, including sleepiness, dizziness, irritability, headache, and psychic disturbances. Ethyl-ether was found to be a mild skin irritant with repeated exposures.