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Methodologic issues in using epidemiologic studies for quantitative risk assessment.

Authors
Stayner-L
Source
Conference on Chemical Risk Assessment in the Department of Defense (DoD): Science, Policy, and Practice. Clewell-HJ III, ed., Cincinnati, OH: American Conference of Governmental Industrial Hygienists, Inc., 1992 Jan; :43-51
Link
NIOSHTIC No.
00211698
Abstract
Methodological issues involved in using epidemiological studies for quantitative risk assessments were discussed. Limitations of studies of laboratory animals were associated with extrapolation of results between species and with the high doses administered to the animals relative to typical human exposures. Major methodological issues and attendant uncertainties related to designing and analyzing epidemiological studies included the following: exposure and dose estimation, confounding, effect modification, sample size and statistical power, length of follow up, latency, and lag periods. Lack of adequate exposure information was most often cited as the reason for not basing risk assessments on epidemiological studies. Confounding by other risk factors is regarded as the single greatest problem when using epidemiological studies in risk assessment. Statistical considerations for performing risk assessments were discussed using data from a NIOSH assessment of lung cancer risk and exposure of workers at a cadmium (7440439) production facility. The lifetime risk for dying from lung cancer after 45 years of exposure to cadmium fumes at the current OSHA standard, 100 micrograms per cubic meter, was predicted to range from five to ten per 100 workers.
Keywords
Epidemiology; Risk-analysis; Hazardous-materials; Statistical-analysis; In-vivo-studies; Laboratory-animals; Dose-response; Lung-cancer; Heavy-metals; Occupational-exposure;
CAS No.
7440-43-9
Publication Date
19920101
Document Type
Conference/Symposia Proceedings
Editors
Clewell-HJ III
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Source Name
Conference on Chemical Risk Assessment in the Department of Defense (DoD): Science, Policy, and Practice
State
OH
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